A Fast and Efficient Deprotection of Aldehydes from Acylals using a Wells-Dawson Heteropolyacid catalyst (H6P2W18O62.24H2O)

G. ROMANELLI, H.J. THOMAS, G. BARONETTI AND J.C. AUTINO.

SYNTHETIC COMMUNICATIONS

Marcel Dekker INC.

Lugar: Nueva York; Año: 2004 vol. 34 p. 1 - 6

0039-7911

A rapid and efficient method for the deprotection of aldehyde 1,1-diacetates is described. The reaction was carried out using a Wells- Dawson type catalyst supported on silica. The catalyst, used in 1% molar quantity, is easily recoverable and reusable and maintains the activity after its use in four consecutive reaction batches. The yield of the deprotection was 92–100% (15 examples including nitrobenzaldehyde 1,1-diacetates). Reaction conditions involve short times and the use of toluene as the solvent; isolation is simple and the products are nearly pure.