Solvent and catalysis-free microwave transesterification of β-ketoesters and its application in the production of long-chain ester monastrol derivatives

E. AGUILERA; A. SATHICQ; I. LICK; M. MURGUIA; M. CASELLA; G. ROMANELLI

Sustainable Chemistry and Pharmacy

Elsevier B.V.

Año: 2024 vol. 37

In this work we report a detailed study of the transesterification reaction of β-ketoesters in sol-vent- and catalyst-free conditions, using microwave irradiation. Different alcohols, includingfatty alcohols, were tested to optimize the reaction conditions. Good yields, without the forma-tion of secondary products, were observed at 150 °C. The compounds obtained were used as start-ing substrates in a Biginelli-type multicomponent synthesis to obtain long-chain ester monastrolderivatives, at 80 °C, with good yields, and generally free of secondary products.