Bacteremic Pneumococcal Pneumonia: a Longitudinal Study in 279 Adult Patients from a Single Center

GENTILE JORGE; HERNANDEZ CLAUDIA; SPARO MONICA; RODRIGUEZ EDGARDO; CERIANI CAROLINA; BRUGGESSER FLORENCIA

Jourmal of Respiratory Infections

University of Louisville

Lugar: Louisville; Año: 2018 vol. 2 p. 47 - 51

2473-2869

Introduction Streptococcus pneumoniae (S. pneumoniae) is the most common cause of community acquired pneumonia (CAP) in adults accounting for most cases of pneumonia hospitalizations and deaths [1-2]. Bacteremic pneumonia is the most frequent invasive pneumococcal disease (IPD) in adults and remains a major cause of morbidity and mortality despite improvements in medical care [2-3]. From older and recent studies, it is estimated that approximately 20% of patients with pneumococcal pneumonia develop bacteremia [3-4], with a mortality rate ranging between 15-35%. More than 50% of S. pneumoniae bacteremia cases occur in elderly patients and most studies show increased pneumococcal-related deaths in this population [1-3-5]. Variations between reported fatality rates might be explained by differences between studied populations including demographic factors, underlying health conditions, severity of illness at the time of admission, and bacterial factors. Also, geographical and temporal situations should be considered. On the other hand, drug resistance does not appear to contribute to mortality or ICU admission rates [5]. Despite the fact that BPP is a frequent and severe disease, there is minimal information regarding BPP in our city. We report here the result of 26-year prospective study in patients with BPP treated in our hospital, to assess local disease incidence, clinical, radiographic and microbiological features, as well as to evaluate factors related to mortality.