INVESTIGADORES
BERGMANN ingrid Evely
artículos
Título:
Phylogenetic analysis of of Foot-and-Mouth Disease Virus type O circulating in the Andean region of South America during 2002-2008
Autor/es:
MALIRAT V,; BERGMANN I.E.; CAMPOS, R.M.; SALGADO, G; SANCHEZ, C.; CONDE, F; QUIROGA, JL; ORTIZ, S
Revista:
VETERINARY MICROBIOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Holanda; Año: 2011 vol. 152 p. 74 - 87
ISSN:
0378-1135
Resumen:
At present, Foot-and-Mouth Disease (FMD) has been successfully controlled in most
territories of South America, where only Ecuador and Venezuela remain as endemic
countries. In this context, the precise characterization of circulating viruses is of utmost
importance. This work describes the first molecular epidemiology study performed with the
complete VP1-coding region of 114 field isolates of FMD virus (FMDV) type O, collected in the
Andean countries mainly during 20022008. Sequences were aligned and compared to
isolates responsible for emergencies in the Southern Cone of the continent between the years
2000 and 2006, and to other representative type O viruses worldwide. The results showed
that FMD type O viruses isolated in South America and analyzed up to date are placed in 11
different lineages within the Euro SA topotype. Five of these lineages included viruses
circulating in Ecuador and Venezuela during 20022008. The last emergencies reported in
already-free areas in the Andean region, showed close relationships with viruses circulating
in these endemic countries. Andean lineages showed a clear separation from the unique
lineage containing viruses responsible for the emergencies in the Southern Cone, reflecting
the different livestock circuits and providing evidence that support the ecosystem dynamics
in the region. A wide geographical dissemination of the same strain in short time intervals
has been observed, pointing to animal movements as the most significant risk parameter.
This fact, together with an important generation of viral variants in areas under weak control
strategies, reinforce the need of stronger official controls, as well as for establishing
multinational cooperative measures in the border areas.