Platinum(II) complexes based on hidroxyquinoline ligands. Antitumor effects in 2D and 3D human osteosarcoma models.

LEON IE; MARTÍN-SANTOS C.; CADAVID VARGAS JF; CABRERA S.; ALEMÁN J.; NAVARRO-RANNINGER C.; ETCHEVERRY SB

Beijing

Simposio; 17th International Conference on Biological Inorganic Chemistry (ICBIC17); 2015

Despite the remarkable success of CDDP (cisplatin)1 in the treatment of different types of cancers, two majorlimitations of the drug are remarkable (i) its dose-limiting effects and (ii) its inactivity against some of themost frequent human tumor types (e. g. colon and lung cancers). These limitations early stressed the necessityfor the search of structural analogues endowed with fewer side effects and capable of overcoming acquiredresistance to CDDP. On the other hand, the hydroxyquinolines derivatives have medicinal properties(antineurodegenerative, anticancer activities, etc). Regarding the anticancer activity of the hydroxyquinolinesdifferent mechanisms of action have been reported 2. In this project we report the biological effects of twocomplexes of platinum(II) with analogous of clioquinolon a 2D (monolayer) and 3D (spheroids) huma nosteosarcoma cell line MG-63. Based on the results of cytotoxic assays in monolayer (2D) it was observed that after 6 h complex 2 caused acell viability inhibition at 10-100 µM while 1 did not show any effects in the same range of concentrations(p