Biog5: A bioinformatic system for the analysis of the Human Papilloma

PEREZ, ERNESTO RAFAEL; ERDOZAIN, SOFÍA; GÓMEZ CHÁVEZ, LEONARDO; CONTI, GERMÁN ANDRES; ANGELINA, EMILIO ; PERUCHENA, NELIDA

Corrientes

Congreso; XII CAB2C Congreso Argentino de Bioinformática y Biología Computacional; 2022

Asociación Argentina de Bioinformática y Biología Computacional

Human papillomavirus (HPV) is classified according to its oncogenic potential intodifferent types ofrisk which are low, high and undetermined. Currently, there are more than 100different types but justthe most prevalent and high-risk ones (nine of them) are currently covered byavailable vaccines. Inaddition, there are several less common strains that can still cause cancer and be resistant tovaccines. Biog5 is a tool that integrates multiple computational biology and bioinformatics tools tofind correlations between all requested HPV strains in sequence analysis and structural data of L1, L2,E1, E2 and E7 proteins. This allows us to assist in diagnostic and outbreak investigations to addressthe virulence and likelihood of vaccine resistance of the less prevalent strains.