ARACHIDONIC ACID RELAXES RAT MESENTERIC ARTERIAL BEDINVOLVING BK ION CHANNEL ACTIVATION

MILESI, MARIA VERÓNICA; MONCADA, MELISA; MARTIN, PEDRO; VECCHIO LE; ENRIQUE, NICOLÁS

Rio de Janeiro

Congreso; 38th World Congress of the International Union of Physiological Sciences; 2017

International Union of Physiological Sciences

Arachidonic acid (AA) is a polyunsaturated fatty acid (PUFA-6) involved in several physiological processes, many times through modulation of ion channels activity. Previously, we reported that 10 µM AA directly activates the high conductance Ca2+ and voltage dependent K+ channel (BK). This effect was observed when the alfa subunit of BK channel was expressed together with the regulatory beta1 subunit, but not in absence of this beta subunit. AA increased the open probability of BK channels and shifted the activation voltage-dependence to the left (ΔV1/2= -55.2 ±4.4 mV, n=3, p