- 174 G>C IL-6 polymorphism and primary iron overload in male patients.

TETZLAFF WF1,2, MEROÑO T3,4, BOTTA EE3,4,5, MARTÍN ME3,4, SORROCHE PB6, BOERO LE3,4, CASTRO M4,7, FRECHTEL GD8, REY J4,7, DARUICH J9, CERRONE GE8,10, BRITES F3,4,5.

ANNALS OF HEMATOLOGY

SPRINGER

Lugar: Berlin; Año: 2018

0939-5555

Primary iron overload (IO) is commonly associated with mutations in the hereditary hemochromatosis gene (HFE). Nonetheless, other genetic variants may influence the development of IO beyond HFE mutations. There is a single nucleotide polymorphism (SNP) at - 174 G>C of the interleukin (IL)-6 gene which might be associated with primary IO. Our aim was to study the association between the SNP - 174 G>C gene promoter of IL-6 and primary IO in middle-aged male patients. We studied 37 men with primary IO diagnosed by liver histology. Controls were age-matched male volunteers (n = 37). HFE mutations and the SNP - 174 G>C gene promoter of IL-6 were evaluated by PCR-RFLP. Logistic regression was used to evaluate the association between primary IO and SNP - 174 G>C gene promoter of IL-6. Patients and control subjects were in Hardy-Weinberg equilibrium for the SNP - 174 G>C gene promoter of IL-6 (p = 0.17). Significantly different genotype frequencies were observed between patients (43% CC, 43% CG, and 14% GG) and control subjects (10% CC, 41% CG, and 49% GG) (OR = 4.09, 95% CI = 2.06-8.13; p C gene promoter of IL-6 (OR = 6.3, 95% CI = 1.9-21.4; p C gene promoter of IL-6 can be proposed as one of the gene variants influencing iron accumulation in male adults with HFE mutations. Studies in larger cohorts are warranted.