BECAS
NOVOA DÍAZ MarÍa BelÉn
artículos
Título:
P-172 PTHrP and SPARC expressions in human colorectal cancer: An in silico analysis
Autor/es:
CARRIERE, P.; NOVOA DIAZ, M.; LOPEZ MONCADA, F.; ZWENGER, A.; CONTRERAS, H.; CALVO, N.; GENTILLI, C.
Revista:
ANNALS OF ONCOLOGY
Editorial:
OXFORD UNIV PRESS
Referencias:
Año: 2021 vol. 32
ISSN:
0923-7534
Resumen:
PTHrP is a paraneoplastic factor involved in the progression and theacquisition of the aggressive behavior of different types of tumors. Employing in vitroand in vivo models of colorectal cancer (CRC), our research group observed thatPTHrP promotes cell survival, proliferation, migration, angiogenesis, epithelial tomesenchymal transition (EMT) program, cancer stem cell (CSC) phenotype, andchemoresistance through different signaling pathways. Recently, in HCT116 cellsderived from CRC we found that PTHrP acts increasing SPARC protein expression, arelevant protein involved in CRC progression. Moreover, SPARC treatment on HCT116cells potentiated PTHrP effects. In vivo model, PTHrP also increased SPARC expression. Based on these findings, the aim of this work is explore the clinical relevance ofPTHrP and SPARC tumor expression in human CRC using in silico analysis.
