Phosphatidic acid mediates neurofilament loss induced by alpha-synuclein

CONDE, MELISA A.; ALZA, NATALIA P.; URANGA, ROMINA M.; SALVADOR, GABRIELA A.

Buenos Aires

Congreso; Reunión Conjunta de sociedades de biociencia- LIII Reunión anual de la Sociedad Argentina de Investigación Bioquímica y Biología Molecular; 2017

In our laboratory, we have previously studied the role of phospholipase-mediated signaling in different models of neuronal injury. In this work, our aim was to characterize the effect of wild type α-synuclein (WT α-syn) overexpression on phospholipase D (PLD) pathway in a human neuroblastoma cell line. Immunocytochemistry showed a significant decrease in the neuronal marker neurofilament (NF) expression and a rise in F-actin foci in WT α-syn cells compared with control cells (pcDNA3) (p