UPREGULATION OF CHOLESTEROL METABOLISM AS A HALLMARK OF MIDBRAIN NEURODEGENERATION INDUCED BY IRON OVERLOAD

MANISCALCHI, ATHINA; BENZI JUNCOS, ORIANA N.; CONDE, MELISA A.; FUNK, MELANIA I.; ALZA, NATALIA P.; SALVADOR, GABRIELA A.

Congreso; REUNIÓN CONJUNTA SAIC SAB AAFE AACYTAL 2023; 2023

Iron (Fe) accumulation in specific brain areas and ferroptosis areassociated with various neurodegenerative disorders. We have previouslyestablished an in vivo model of Fe overload (C57BL/6 micetreated with Fe 333 mg/kg) with midbrain neurodegeneration andlipid cacostasis. Our aim was to study the link between lipid metabolismalterations and ferroptosis taking into account neuroglialmetabolism. In midbrain of Fe-overloaded animals, we detected adecrease in the expression of SLC7A11 and an increase in ACSL4(p