LIPID DROPLETS AS YING-YANG MARKERS OF NEURODEGENERATION IN MODELS OF SYNUCLEINOPATHIES

ALZA, NATALIA P.; CONDE, MELISA A.; MANISCALCHI, ATHINA; BENZI JUNCOS, ORIANA N.; FUNK, MELANIA I.; SALVADOR, GABRIELA A.

Congreso; REUNIÓN CONJUNTA SAIC SAB AAFE AACYTAL 2023; 2023

Alpha-synuclein (aSyn) pathology is a hallmark in the onsetand progression of several synucleinopathies, includingParkinson’s disease. It has been demonstrated thatlipid disturbances are associated with aSyn pathology.Our aim was to study neutral lipid metabolism in severalin vivo and in vitro models of aSyn accumulation. To thisend, different forms of aSyn overexpressed in neuronsand toxicant-induced animal models related with synucleinopathieswere used. In neuronal cultures, we demonstratedthat the overexpression of aSyn (WT and mutantA53T) induced the accumulation of lipid droplets (LD)and free cholesterol (p