Novel insights into neuron-glia communication: the case of neuroinflammation triggered by the pesticide Maneb

BENZI JUNCOS, ORIANA N.; CONDE, MELISA A.; ALZA, NATALIA P.; SALVADOR, GABRIELA A.

Congreso; 3rd FALAN Congress; 2022

Maneb is a dithiocarbamate pesticide which prolonged use is considered an environmental risk factor for Parkinson’s disease (PD). An important component in PD pathogenesis is neuroinflammation. Chronic neuroinflammation is established when resolution process fails to limit pro-inflammatory stimulus, thus triggering neuronal death.Prostaglandins and resolvins are specialized and essential lipid mediators in the inflammation/resolution process. They are oxygenated derivatives of arachidonic (AA) and docosahexaenoic (DHA) acids that act as ligands for specific G-protein coupled receptors.