WIRED CHOLESTEROL METABOLISM IS RELATED WITH FERROPTOSIS LEADING TO PARKINSONISM-LIKE DISORDERS

MANISCALCHI, ATHINA; BENZI JUNCOS, ORIANA N.; CONDE, MELISA A.; FERMENTO, EUGENIA; FUNK, MELANIA I.; CURINO, ALEJANDRO; FACCINETTI, MARÍA MARTA; ALZA, NATALIA P.; SALVADOR, GABRIELA A.

Congreso; REUNIÓN CONJUNTA SAIC SAI & FAIC SAFIS 2022; 2022

Ferroptosis is a novel type of oxidative and non-apoptotic cell deathassociated with neurodegenerative disorders. Previously, we haveestablished an in vivo model of iron overload (C57BL/6 mice treatedwith iron-sucrose) that triggers ferroptosis in the nervous systemrelated with markers of neurodegeneration. Our aim was to characterizelipid metabolism alterations in mice midbrain of this experimentalmodel. We found that midbrain lipid content was altered byiron overload. Cholesterol and diacylglycerol levels were increased(p