INSULIN LIKE GROWTH FACTOR (IGF) SYSTEM COMPONENTS IN PEDIATRIC TUMORS OF CENTRAL NERVOUS SYSTEM (CNS): ASSOCIATION WITH CLINICAL OUTCOME. A KEY ROLE FOR IGF-2?

MARTIN, A.; CLEMENT, F; VENARA, M.; MAGLIO, S; MATHO, C.; GARCIA LOMBARDI, M; BERGADÁ I; PENNISI, P

washington

Congreso; 10th International Meeting of Pediatric Endocrinology; 2017

CNS tumors are the most frequent solid tumors in pediatric population. The IGFsystem of ligands and receptors are known to play an important role in both normaland neoplastic growth. Quantitation of components of this system have beenreported in adult CNS tumors, but information from pediatric patients is scarce. Ouraim was to characterize the expression of IGF-1, IGF-1R, IGF-2 and IR in pediatricCNS tumors and its association with clinical outcome.