Components of the Insulin-Like Growth Factor (IGF) System in Paediatric Gliomas Upon Diagnosis According to WHO 2007 Grading

CLÉMENT, F; MARTIN, A; VENARA, MARCELA; MAGLIO, S; MATHO, C; GARCÍA LOMBARDI, M; BERGADÁ, I; PENNISI, P

Puerto Varas

Congreso; XXV Annual Meeting of the Latin American Pediatric Endocrinology Society (SLEP; 2015

Sociedad Latinoamericana de Endocrinologia Pediátrica (SLEP)

Gliomas are the most common central nervoussystem tumours in children. Histologic grading is a means of predictingthe biological behavior of these tumours and survival isstrongly correlated with tumour gradation. The insulin-likegrowth factor (IGF) system of ligands and receptors are known toplay an important role in both normal and neoplastic cellulargrowth. Information about the association of IGF-1, IGF-2, InsulinReceptor (IR) isoforms and IGF-1 receptor intracellular localizationwith tumour grading in paediatric gliomas is lacking.