Male Central Precocious Puberty: Serum Profile of Anti-Müllerian Hormone and Inhibin B before, during, and after Treatment with GnRH Analogue

GRINSPON ROMINA; ANDREONE LUZ; BEDECARRAS PATRICIA; ROPELATO MARIA GABRIELA; REY RODOLFO A; CAMPO STELLA; BERGADA IGNACIO

International Journal of Endocrinology

Hindawi Publishing Corporation

Lugar: New York; Año: 2013 vol. 2013 p. 1 - 6

1687-8337

We aimed to describe the functional changes of Sertoli cells, based on the measurement of serum anti-M¨ullerian hormone (AMH) and inhibin B during treatment with GnRHa and after its withdrawal in boys with central precocious puberty. Six boys aged 0.8 to 5.5 yr were included. AMH was low at diagnosis in patients >1 yr but within the normal range in younger patients. AMH increased to normal prepubertal levels during treatment. After GnRHa withdrawal, AMH declined concomitantly with the rise in serum testosterone. At diagnosis, inhibin B was elevated and decreased throughout therapy, remaining in the upper normal prepubertal range. In patients with testicular volume above 4mLAMHremained higher in spite of suppressed FSH.After treatment withdrawal, inhibin B rose towards normal pubertal levels. In conclusion, AMHdid not decrease in patients