The physics of irradiation of biological matter by ion beams: Hadrontherapy.

M. A. QUINTO; J.M. MONTI; C. A. TACHINO; PHILIPPE F. WECK; O.A. FOJÓN; C. CHAMPION; R. D. RIVAROLA

Córdoba

Conferencia; 14th International Symposium on Radiation Physics; 2018

In radiobiology, predicting the evolution of irradiated biological samples still isnowadays an active field of research to identify DNA lesions or to adapt theradiotherapeutic protocols in radiation oncology. In this context, the numericalmethods, based on Monte Carlo track-structure simulations, represent the mostsuitable and powerful tools for understanding the radiobiological damage in-duced by ionizing particles. However, most existing Monte Carlo track-structurecodes require a large set of input data (cross sections) aiming at describing atthe atomic scale the various particle-induced interactions in the medium of inter-est (water in liquid/vapor phase and DNA). In the present work, we report thetheoretical differential and total cross sections, computed within a quantum me-chanical continuum distorted wave-eikonal initial state (CDW-EIS) approach,for ion impact in water vapor and on DNA. These cross sections have been usedto build up the input database for the homemade Monte Carlo track-structureTILDA-V. A comparison between the theoretical prediction and the availableexperimental data is presented. Micro-dosimetry results obtained with TILDA-V are also reported.