Infection with T. cruzi and the generated immunological memory inhibit tumor growth in C57BL/6 mice challenged with the B16-F10 cell line

KAUFMAN, CINTIA DANIELA; ALLOATTI, ANDRÉS

Mar del Plata

Congreso; LXX Reunión Anual de la Sociedad Argentina De Inmunología (SAI) & 3er Congreso Franco-Argentino De Inmunología (FAIC); 2022

Sociedad Argentina de Inmunología

The spontaneous regression of tumor is often associated with infections. In these cases, pre-existing memory T cells generated in response to microorganisms could recognize tumor antigens that share sequences with microbial epitopes (Hoption Cann, van Netten & van Netten, 2003).In our previous experiments both, the acute infection of Trypanosoma cruzi -the etiological agent of Chagas Disease- and the immunological memory generated in response to the infection, inhibited the tumor growth in C57BL/6 mice challenged with B16-F10 cells (murine metastatic melanoma), although at different degrees (FIGURE 1A). Interestingly, the infiltration of specific CD8+ T lymphocytes against T. cruzi (Tskb20+) was observed in both experimental groups (FIGURE 1B).