BECAS
MARTÍN Pamela LucÍa
congresos y reuniones científicas
Título:
IMPAIRMENT OF ENDOGENOUS BILIRUBIN GENERATION AGGRAVATES BILE-DUCT LIGATION INJURY IN RATS: ROLE OF BILIRUBIN ANTIOXIDANT EFFECTS
Autor/es:
MARTÍN, PAMELA L; RAZORI, MARÍA V; CORBO, M. LUJAN; HARVEY, GUILLERMINA B.; SANCHEZ POZZI, ENRIQUE; ROMA, MARCELO G.; BASIGLIO, CECILIA L.
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biociencias; 2022
Institución organizadora:
Sociedad Argentina de Investigación Clínica
Resumen:
We showed that hemeoxygenase-1 (HO1) induction, and consequent bilirubin (BR) elevation,protects the liver from oxidative stress (OS)-induced cholestasis in vivo. Here, we evaluated theeffect of HO1 inhibition on the endogenous levels of BR and its protective action in obstructivecholestasis. Male Wistar rats were subjected to 7-day bile-duct ligation (BDL, n=7) or shamsurgery (Sh, n=5). HO1 was inhibited with Zn(II) protoporphyrin IX (PP, 25 mg/Kg b.w., i.p.), 24hbefore BDL (PP+BDL, n=10) or Sh (PP+Sh, n=6). Results are expressed as media±SD andanalyzed by Kruskal-Wallis test. After BDL, plasma BR levels (mg/dl) were higher in BDL(8.46±1.70a) than in PP+BDL (3.90±2.80b), confirming HO1 inhibition (ap
