Adsorption/desorption study of antibiotic and anti-inflammatory drugs onto bioactive hydroxyapatite nano-rods

BENEDINI, LUCIANO; PLACENTE, DAMIÁN; RUSO, JUAN; MESSINA, PAULA

MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS

ELSEVIER SCIENCE BV

Año: 2019 vol. 99 p. 180 - 190

0928-4931

The use of high doses of antibacterial and anti-inflammatory drugs for patients with bone diseases, associated toimplants or bone filling, can develop adverse effects; and consequently, it promotes to think new strategies toavoid this problem. In this work, it has been described the adsorption/release (or desorption) behavior of twodrugs, ciprofloxacin (CIP) and ibuprofen (IBU), onto hydroxyapatite (nano-HA) at 37 °C. Through Ultraviolet-Visible (UV?Vis) spectroscopy, the concentrations of both drugs in adsorption, kinetic and desorption processeswere obtained. The Fourier Transformed-Infrared (FT-IR) spectroscopy, Zeta-potential (ζ-potential), High-Resolution Transmission Electron Microscopy (H-TEM) and x-Ray Diffraction (xRD) were also used to characterizebared nanoparticles and those with adsorbed drugs. Five adsorption models (Langmuir, Freundlich, Sips,Temkin and Dubinin-Radushkevich) were used for describing the behavior of both active compounds. The adsorptionprocesses (CIP/nano-HA and IBU/nano-HA) were better predicted by the Sips model than by the others.The kinetic adsorption data were processed, for both active agents, by application of Avrami´s model.Desorption/release process (of both drugs) was evaluated though Korsmeyer-Peppas (K-P) model. Owing to thepredictability of these systems, we propose the use of these active ceramics as potential bone filler for improvingthe treatment against bacterial bone infections and to avoid its associated inflammatory process.