CHARACTERIZATION OF THE GHRELIN-RESPONSIVE NEURONS OF THE LATERAL HYPOTHALAMIC AREA

BARRILE, FRANCO; DE FRANCESCO, PABLO NICOLÁS; CORNEJO, MARÍA PAULA; REYNALDO, MIRTA; PERELLO, MARIO

Congreso; Congreso de la Sociedad Argentina de Investigación en Neurociencias; 2019

The lateral hypothalamic area (LHA) controls feeding, energy balance, motivated behavior, among other functions.LHA expresses high levels of the ghrelin receptor (or, growth hormone secretagogue receptor, GHSR). Ghrelin is astomach-derived peptide that regulates diverse metabolic functions exclusively via GHSR. Here, we characterizedthe GHSR expressing neurons of the LHA (hereafter named GHSR-LHA neurons) using a mouse model, in which theexpression of enhanced green fluorescent protein is controlled by the GHSR promoter (GHSR-eGFP mice).