PLATELET SEROTONIN IN ALCOHOLIC PATIENTS, IN RELATION TO EFFICIENCY OF CLOMETIAZOL. CART EFFECTS.

LLINAS CARRILLO S; LEYTES E; ABUD M; PONCE C; CEJUDO C; CAYADO GUTIÉRREZ N; BIANCHI RA

Mendoza

Congreso; XXVI Reunión Anual de la Sociedad de Biología de Cuyo; 2008

Sociedad de Biología de Cuyo

The relation of serotonine and alcoholism is a recognized fact in the international literature. The relation between the serotoninergic neurotransmision and the Alcohol Abstinence Syndrome (AAS) shows some experimental published results. In the present work there is valued the effect of two tranquilizing medicaments for the AAS: clometiazol and clordiazepoxid and its relation with the levels of plateret serotonin and serotonin captures. A clinical test was realized Phase III randomized. Criteria diagnosis and selection from the Manual of diagnosis and statistics DSM IV are used, as well as scales of global clinical impressions and of the AAS. The clinical test included fifty male patients, aged average from 35 to 45, in which samples of blood were obtained trough Venous puncture(10 ml) in order to obtain enriched platelet plasma. These tests were realized at the first and tenth day of treatment. The efficiency of clometiazol on the serotonin functioning in the treatment of AAS were evaluated, as well as comparisons with the effect of clometiazol on the capture of platelets serotonine. Serotonine capture and platelet serotonine values showed statistically significant results (p