Hsp27 (HSPB1): a possible surrogate molecular marker for loss of heterozigocity (LOH) of chromosome 1p in oligodendrogliomas. Correlation with histopathologic grade, Hsp70 (HSPA), PCNA, ?Ò-catenin, p53 and MGMT.

GISELA N CASTRO, NIUBYS CAYADO GUTIÉRREZ1, VERA L. MONCALERO , PATRICIA LIMA, RODOLFO LUCERO DE ANGELIS, VICTOR CHÁVEZ, FERNANDO D CUELLO-CARRIÓN, DANIEL R CIOCCA.

Buenos Aires

Workshop; Workshop "Frontiers in BioScience"; 2012

Ministerio de Ciencia, Tecnologia e Innovacion Productiva y Sociedad Max Planck (Alemania).

Heat shock proteins (HSPs) are implicated in the genesis as well as in the progression of cancer. High HSP levels have been reported in central nervous system tumors, particularly in gliomas. Malignant gliomas comprise a wide variety of tumors from astrocytomas to oligodendrogliomas. Among the theories for cancer causation is emerging the concept of ?obligate haploinsufficiency? in which partial loss of tumor suppressor genes is more tumorigenic than complete loss. In oligodendrogliomas 1p LOH is a predictor of good prognosis and treatment response. In contrast, in uveal melanomas LOH of chromosome 3 has been linked to poor prognosis and down-regulation of Hsp27.In oligodendroglial tumors Hsp27 could be a surrogate marker of 1p LOH helping to predict the prognosis of the disease. In astrocytomas, Hsp27, Hsp70,beta-catenin and p53 are more frequently expressed in high-grade astrocytomas.We showed significant interrelationships between the investigated molecular markers and clinicopathological characteristics in diffuse gliomas, suggesting that some of these markers could predict the disease outcome and the response to treatments.