THE THYROID STATUS MODULATES THE TUMOR MICROENVIRONMENT AND THE ANTITUMOR IMMUNE RESPONSE IN BREAST CANCER

STERLE HA; HILDEBRANDT X; GUTIERREZ ML; PAULAZO MA; CAYROL MF; DIAZ FLAQUE MC; ROSEMBLIT C ; BOLONTRADE M; CREMASCHI GA

Buenos Aires

Congreso; XVII Latin American Thyroid Society Congress; 2019

Latin American Thyroid Society

Introduction:Several findings suggest that the patient?s hormonal context plays a crucial role in determining the outcome of cancer. However, very little is known about the nature of thyroid hormone action on tumor growth. AIM:To evaluate the effect of thyroid status on triple negative breast cancer (TNBC) development. MethodsBalb/c mice were orthotopically inoculated with 4T1 cells after the treatment with thyroxine (12mg/l) for 30 days or propylthiouracil (500mg/l) for 15 days in the drinking water to obtain hyperthyroid (hyper) or hypothyroid (hypo) mice, respectively. ResultsHyper mice showed increased tumor growth rate compared to controls (p