INVESTIGADORES
ROSEMBLIT Cinthia
congresos y reuniones científicas
Título:
Oncodriver inhibition and Th1 cytokines cooperate to induce tumor senescence and apoptosis in HER2 and triple negative breast cancer (TNBC)
Autor/es:
CINTHIA ROSEMBLIT ; JASHODEEP DATTA ; LEA LOWENFELD; SHUWEN XU; KRITHIKA KODUMUDI; DORIS WIENER; GRACIELA A CREMASCHI; BRIAN J CZERNIECKI
Lugar:
Capital Federal
Reunión:
Congreso; Reunion Conjunta de Sociedades Biomedicas; 2017
Institución organizadora:
Sociedad Argentina de Investigaciones Clínicas
Resumen:
Immune infiltration of breast cancer predicts favorable outcomes. We have described the loss of anti-oncodriver Th1 immunity during breast tumorigenesis. We studied the role that Th1 cytokines may play in the induction of tumor senescence and apoptosis of breast cancer cells.HER2positive cells were sensitive to senescence induction when cultured with IFN-γ and TNF-α in a dose dependent manner measured by β-galactosidase activity (p
