INVESTIGADORES
ROSEMBLIT Cinthia
congresos y reuniones científicas
Título:
The thyroid status regulates triple negative breast cancer (TNBC) growth and metastasis through the modulation of mesenchymal stromal cell (MSC) migration and antitumor immune response
Autor/es:
HELENA A STERLE; HILDEBRANDT X; GUTIERREZ ML; PAULAZO MA; CAYROL F; DÍAZ-FLAQUÉ MC; ROSEMBLIT C; BOLONTRADE M; CREMASCHI GA
Reunión:
Congreso; Reunión Conjunta SAIC, SAI, SAFIS; 2018
Institución organizadora:
Sociedad Argentina de Investigaciones Clínicas
Resumen:
The association between thyroid disease and breast cancer riskremains unclear. Our aim was to evaluate the effect of thyroidstatus on TNBC development. For this, Balb/c mice were orthotopicallyinoculated with 4T1 cells after the treatment with thyroxine(12mg/l) for 30 days or propylthiouracil (500mg/l) for 15 days in thedrinking water to obtain hyperthyroid (hyper) or hypothyroid (hypo)mice, respectively. An increased tumor growth rate, that becameevident at day 21 post-inoculation (p.i.), was seen in hyper micecompared to controls (p
