Enzyme-Like Complexity in the Pores of Metal-Organic Frameworks

A. M. FRACAROLI; R. H. DE ROSSI; O. M. YAGHI

Tsukuba

Workshop; 2nd MANA Reunion Workshop; 2018

Metal-organic frameworks (MOFs) are an extensive class of crystalline and porous materials that show promise in several fields due to their adjustable chemical functionality, structural diversity, and ease of post-synthetic functionalization1.To achieve enzyme-like complexity within the pores of a MOF, it is necessary to perform multiple covalent-bond-formation reactions on the crystals without losing access to its interior or crystallinity. Here, I present that seven post-synthetic reactions in tandem can be successfully achieved within the pores of a multivariate MOF (MTV-IRMOF-74-III), to covalently incorporate tripeptides that resemble the active sites of enzymes in their spatial arrangement and compositional heterogeneity.These reactions build up H2N-Pro-Gly-Ala-CONHL and H2N-Cys-His-Asp-CONHL (where L = organic struts) amino acid sequences without losing porosity or crystallinity. Preliminary findings indicate that the complexity thus achieved can affect reactions that were previously accomplished only in the presence of enzymes.