INVESTIGADORES
DAMIANI Armando Mario
artículos
Título:
Recombinant equine herpesvirus 1 (EHV-1) vaccine protects pigs against challenge with influenza A(H1N1)pmd09
Autor/es:
SAID A, LANGE E, BEER M, DAMIANI A, OSTERRIEDER N
Revista:
VIRUS RESEARCH
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 173 p. 371 - 376
ISSN:
0168-1702
Resumen:
Swine influenza virus (SIV) is not only an important respiratory pathogen in pigs but also a threat to
human health. The pandemic influenza A(H1N1)pdm09 virus likely originated in swine through reassortment
between a North American triple reassortant and Eurasian avian-like SIV. The North American
triple reassortant virus harbors genes from avian, human and swine influenza viruses. An effective vaccine
may protect the pork industry from economic losses and curb the development of new virus variants
that may threaten public health. In the present study, we evaluated the efficacy of a recombinant equine
herpesvirus type 1 (EHV-1) vaccine (rH H1) expressing the hemagglutinin H1 of A(H1N1)pdm09 in the
natural host. Our data shows that the engineered rH H1 vaccine induces influenza virus-specific antibody
responses in pigs and is able to protect at least partially against challenge infection: no clinical
signs of disease were detected and virus replication was reduced as evidenced by decreased nasal virus
shedding and faster virus clearance. Taken together, our results indicate that recombinant EHV-1 encoding
H1 of A(H1N1)pdm09 may be a promising alternative for protection of pigs against infection with
A(H1N1)pdm09 or other influenza viruses.