Molecular basis of ABC transporters regulation by insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in hepatocellular carcinoma (HCC)

BUCCI-MUÑOZ M; ANSELMINO L.E; GOLA A.M.; LIVORE V.I.; MOTTINO A.D.; RIGALLI J.P; RUIZ M. L

Ciudad Autónoma de Buenos

Congreso; REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE FISIOLOGÍA; 2023

Previously, we showed that IGF2BP1 knockdown (KD) leads to a decrease in ABCB1 and ABCC3 expression (protein and mRNA). Sorafenib (SFB) treatment induced IGF2BP1, ABCB1 and ABCC3 expression and KD of IGF2BP1 prevented the induction of ABCB1 expression, ABCC3 induction was prevented only at the mRNA level. To study the molecular mechanism of ABC transporter regulation by IGF2BP1 and its influence on SFB chemotherapy.