Effects of Fermented Goat Milk on Adiposity and Gut Microbiota in a Diet-Induced Obesity Murine Model

MARQUEZ, ANTONELA; RUSSO, MATÍAS; TOMEI, CARLOS; CASTELLANO, PATRICIA; PUGLISI, EDOARDO; MEDINA, ROXANA; GAUFFIN-CANO, PAOLA

Fermentation

Multidisciplinary Digital Publishing Institute

Año: 2024 vol. 10

The administration of goat milk fermented (FGM) with Lactobacillus delbrueckii subsp. indicusCRL1447 and supplemented with different mixes of lactobacilli strains (Mix1: Limosilactobacillusfermentum CRL1446 + Lactiplantibacillus paraplantarum CRL1449 + Lactiplantibacillus paraplantarumCRL1472; Mix2: CRL1446 + CRL1449; Mix3: CRL1446 + CRL1472; and Mix4: CRL1449 + CRL1472)was investigated regarding body weight, metabolic and inflammatory parameters, and gut microbiota(GM) composition in mice fed a high-fat diet (HFD). Body weight gain, adipocyte size, fasting bloodglucose, serum triglyceride, and leptin levels were significantly reduced in the group fed FGM+Mix3compared with the obese mice fed FGM. FGM+Mix2 and FGM+Mix3 modified the GM composition,reversing the dysbiosis caused by the HFD. Although there were no significant changes at the phylumlevel, the GM composition was significantly changed at the family and genus levels. Results suggestthat the administration of FGM+Mix3 improves metabolic and immune profiles in obese mice whilepositively modulating the GM, therefore attenuating the risk factors associated with obesity.