The UV filter BP-3 induces intrauterine growth restriction by affecting the remodeling of spiral arteries

ZENCLUSSEN, MARÍA LAURA; GALLEANI, VALENTINA; ABUD J.E.; RODRIGUEZ, HORACIO A.

Mar del Plata

Congreso; REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2021 SAIC - SAI - AAFE - NANOMED-ar; 2021

SAIC - SAI - AAFE - NANOMED-ar

We are continuously exposed to personal care products containing chemicals that may affect our health. In previous works we have shown that dermal exposure to a commonly used UV-filter, benzophenone-3 (BP3) affected fetal growth of the progeny in mice. The aim of the present study was to evaluate the underlying mechanism of the effects of BP3 on fetal weight. For that purpose, C57BL6 mice were dermally exposed either to BP3 (50 mg/kg/day) or to vehicle (olive oil) on a daily basis, from gestational day 0 (gd0) until their sacrifice on gd10 or gd14. In the groups of animals sacrificed on gd10, there was a significant difference in the size of the whole implantation sites (WIS), being the WIS of the BP-3 treated animals smaller than those of the control group (p