Synthesis and characterization of multilayer core-shell nanoprobes based on Metal-Enhanced FRET for biosensing applications

DANNY BROUARD, LUC RAINVILLE, MAXIME RIOUX, A.-GUILLERMO BRACAMONTE, MATHIEU L.-VIGER, AND DENIS BOUDREAU

Toronto

Congreso; CSC, Canadien society for chemistry 2010; 2010

Our research group is working on the development of multilayer core-shell nanoparticles (NPs) featuring a metal core surrounded by concentric silica layers containing fluorophores positioned at precise distances from the core. Recent results show that the controlled geometry of these core-shell NPs enhances fluorescence intensity and photostability several-fold through plasmonic coupling with the core and improves Förster Resonant Energy Transfer (FRET) efficiency and range between donoracceptor pairs. These enviable characteristics make such multilayer core-shell NPs a promising alternative to improve detection sensitivity, photostability as well as FRET range and efficiency in a variety of applications.and improves Förster Resonant Energy Transfer (FRET) efficiency and range between donoracceptor pairs. These enviable characteristics make such multilayer core-shell NPs a promising alternative to improve detection sensitivity, photostability as well as FRET range and efficiency in a variety of applications.These enviable characteristics make such multilayer core-shell NPs a promising alternative to improve detection sensitivity, photostability as well as FRET range and efficiency in a variety of applications.