Hybrid Silica Nano-Biostructure assemblies with perspectives within micro-devices

A. GUILLERMO BRACAMONTE; LUNA R. GOMEZ-PALACIOS

Congreso; IV Jornadas de Jóvenes Bionanocientificxs (JoBioN); 2022

In this research work, it was showed the deposition of silica nanoparticles on Escherichia Coli bacteria by non-covalent interaction between the silanized surfaces and polar components of the biomembrane. [1] This hybrid architecture showed stable conformation characteristics evaluated with different Microscopy techniques such as Bright Field Confocal Microscopy and Transmission Electron Microscopy (TEM). Nano-bio-architectures were detected within colloidal dispersions and in the absence of aqueous media. Nano-bio-interactions were related to strong polar and hydrogen bridges non-covalent interactions. However, to evaluate their stabilities and inter-nano-biostructure interactions, size distributions within variable periods were determined. By this manner, variable nano-bio-aggregate sizes were recorded according to nanoparticles and bacteria concentrations. In similar manner, it was observed an effect of time in their inter-Nano-Biostructure interactions and dynamics determined by Dynamic Light Scattering. [2] Here, it was discussed and evaluated the dynamics and nano-bio-optics properties of E. coli. with Hybrid mono-colored Silica Nanoparticles by incorporation of an Organic Laser Dye. So, the nano-biostructures could not be considered as static systems. However, their interactions are regarded as important factors for dispersibility, stability and effects against additional chemical agents such as antibiotics, as for example. Current experiments in progress and perspectives were discussed focused on potential applications such as Hybrid Nano-Micro-machines, Micro-swimmers, Implantable Cargo Nano-Bio-loaded platforms, and Microdevices.[3]