"A comparative study of bacteriostatic activity of synthetic hydroxilated flavonoids".

OLIVELLA M, ZARELLI V, PAPPANO N AND DEBATTISTA N

BRAZILIAN JOURNAL OF MICROBIOLOGY

SOC BRASILEIRA MICROBIOLOGIA

Año: 2001 vol. 32 p. 229 - 232

1517-8382

Among other properties, flavonoids present a notable bacteriostatic activity. In this paper, minimal inhibitory concentrations (MICs) of 5,7,4´-trihydroxyflavanone (naringenin), 5,7-dihydroxyflavone and 2´,4´,4- trihydroxychalcone (isoliquitirigenin) against Staphylococcus aureus ATCC 25 923 were determined and compared to values obtained for other chalcones and flavanones previously investigated. Specific growth rates and MICs were determined by a turbidimetric kinetic method. The observed sequence MICflavanone (inactive) mayor que MIC7-hidroxyflavanone (197.6 µgml-1) mayor que MIC5,7,4´-trihydroxyflavanone (120 µgml-1) showed that the introduction of an electron donating group (-OH) causes an increase in bioactivity. On the other hand, the comparisons MIC5,7,4´-trihydroxyflavanone (120 µgml-1) mayor que MIC2´,4´,4-trihydroxychalcone (29 µgml-1) and MIC5,7-dihydroxyflavone (105 µgml-1) mayor que MIC2´,4´-dihydroxychalcone (28.8 µgml-1) indicated that the chalcone structure is the most favourable for bacteriostatic activity within the flavonoid family.