Fast Field Cycling Magnetic Resonance Imaging a way to develop new types of contrast

GONZALO RODRIGUEZ; AGUSTIN ROMERO; ALEXIS BERTÉ; ESTEBAN ANOARDO

Ciudad Autónoma de Buenos Aires

Taller; IV Taller de Resonancia Magnética; 2018

Fast Field Cycling Magnetic Resonance Imaging (FFC-MRI) is an emerging technique that allows tomake images at different magnetic field intensities [1-3]. Furthermore, it is possible to perform imagesat low magnetic fields (from earth magnetic field or less until 0.5 T). These abilities make possible tomaximize the contrast by T1 for heterogeneous samples. For example, the T1 contrast between gray andwhite matter is maximized at 0.25 T [4]. In addition, FFC-MRI is a versatile technique which is ideal toexplore new types of contrast and possibilities as double resonance [5], temperature maps and others.In particular, these topics could be applied to improve clinical diagnosis. In this work we present theperformance of a homemade FFC-MRI system. This includes images weighted by T1, T1 inverted anddispersion contrasts, maps of temperature between others. Each one of these researches could be usedas support for the project ?IDentIFY -Improving Diagnosis by Fast Field-Cycling MRI?. This projecthas the purpose of developing the first FFC-MRI system for human clinical diagnosis in the year 2020.[1]- D. J. Lurie, M. A. Foster, D. Yeung, J. M. Huntchison, Design, construction and use of a large-sample field-cycled pedri imager, Phys. Med. Biol. 43 (1998) 1877-1886.[2]- N. I. Matter, G. C. Scott, T. Grafendorfer, A. Macovski, S. M. Conolly, Rapid polarizing fieldcycling in magnetic resonance imaging, IEEE Trans. Med. Imag. 25 (2006) 84-93.[3]- K. M. Gilbert, W. B. Handler, T. J. Scholl, J. W. Odegaard, B. A. Chronik, Design of field-cycledmagnetic resonance systems for small animal imaging, Phys. Med. Biol. 51 (2006) 2825-2841.[4]- H. Fischer, P. A. Rinck, Y. V. Haverbek, R. N. Muller,sell, J. R. Mallard, Nuclear Relaxation ofHuman Brain Gray and White Mater: Analysis of Field Dependence and Implications for MRI. J.Magn. Reson. In Med. 16 (1990) 317-334.[5]- D. J. Lurie, J. M. Hutchison, L. H. Bell, I. Nicholson, D. M. Bussell, J. R. Mallard, Field-cycledproton-electron double-resonance imaging of free radicals in large aqueous samples. J. Magn. Reson.84 (1989) 431-437.