BECAS
PRADA GORI Denis Nihuel
artículos
Título:
Synthesis of propargylamines via the A 3 multicomponent reaction and their biological evaluation as potential anticancer agents
Autor/es:
MARTINEZ-AMEZAGA, MAITENA; GIORDANO, ROCÍO A.; PRADA GORI, DENIS N.; PERMINGEAT SQUIZATTO, CATERINA; GIOLITO, MARÍA V.; SCHAROVSKY, O. GRACIELA; ROZADOS, VIVIANA R.; RICO, MARÍA J.; MATA, ERNESTO G.; DELPICCOLO, CARINA M. L.
Revista:
ORGANIC & BIOMOLECULAR CHEMISTRY
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: CAMBRIDGE; Año: 2020 vol. 18 p. 2475 - 2486
ISSN:
1477-0520
Resumen:
Propargylamines have gained importance in the area of anticancer research. We synthesized 1-substitutedpropargylic tertiary amines using the A3-coupling as the key step. Both, solution and solid-phase proto-cols, were used to provide a library of 1-substituted propargylic tertiary amines with interesting structuraldiversity. The triple negative breast cancer subtype is the most aggressive and it lacks effective therapeutic options, while pancreatic cancer is one of the neoplasms with worse prognosis and limited therapeuticpossibilities. The development of tumor-selective drugs has always been a major challenge in cancertreatment. From our library, two propargylamines displayed a high degree of cytotoxic selectivity. Theselevels of selectivity give a very interesting perspective for further development of 1-substituted propargylictertiary amines as new potential chemotherapeutic antitumor agents