PLZF-RARΑ ENHANCES METABOLIC PLASTICITY AND ROS SCAVENGING INAML CELLS

ALESSANDRA ZAZA; MARIANA GALLO; BRUNELLA BISCUSSI; DANIELA F. ANGELINI; GLORIA PASQUALINI; GIANFRANCO CATALANO; ELISABETTA DE MARINIS; THELMA PERTINHEZ; MARIA TERESA VOSO; ADRIANO VENDITTI; CLARA NERVI; NELIDA INES NOGUERA

Congreso; EHA2023 Hybrid Congress; 2023

European Hematology Association

PLZF-RARα (ZBTB16-RARα) fusion protein binds retinoic acid response elements (RARE) to repress transcriptionof genes essential for myeloid maturation and differentiation, driving a rare acute promyelocytic leukemia (APL)variant (2% of APLs). Metabolic reprogramming is the hallmark of cancer: it confers increasing flexibility innutrient uptake and supports cell growth and malignant progression