Photochromic Azoderivatives for Acetylcholinesterase Inhibition

BISCUSSI, BRUNELLA; SEQUEIRA, MARIA ALEJANDRA; MURRAY, ANA PAULA

Proceedings

MDPI

Lugar: Basilea; Año: 2019 vol. 41

Abstract: We present microwave-assisted synthesis and in vitro acetylcholinesterase inhibition ofdi-PRLC4OAzo, a new azoderivative designed on the basis of aza-stilbene active compounds,already reported by the group. From the total series of azoderivatives synthetized, di-PRLC4OAzoshowed the powerful in vitro enzymatic response for its (E) isomer (IC50: 1.08 μM) by Ellman?s assay,beside a stable photostationary state monitored by UV/Vis absorption spectroscopy, indicating itmight be an efficient photo-responsible probe to remote control the activity of the enzyme.Keywords: microwave-assisted synthesis; acetylcholinesterase; azobenzene; photomodulation