PB1787: PLZF-RARΑ ENHANCES METABOLIC PLASTICITY AND ROS SCAVENGING IN AML CELLS

ZAZA, ALESSANDRA; GALLO, MARIANA; BISCUSSI, BRUNELLA; ANGELINI, DANIELA F.; PASQUALINI, GLORIA; CATALANO, GIANFRANCO; DE MARINIS, ELISABETTA; PERTINHEZ, THELMA; VOSO, MARIA TERESA; VENDITTI, ADRIANO; NERVI, CLARA; NOGUERA, NELIDA INES

HemaSphere

Wolters Kluwer Health

Año: 2023 vol. 7

Background: PLZF-RARα (ZBTB16-RARα) fusion protein binds retinoic acid response elements (RARE) to repress transcription of genes essential for myeloid maturation and differentiation, driving a rare acute promyelocytic leukemia (APL) variant (2% of APLs). Metabolic reprogramming is the hallmark of cancer: it confers increasing flexibility in nutrient uptake and supports cell growth and malignant progression