Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells

GRUMELLI S; ISLAN GA; CASTRO GR

Pulmonary and Critical Care Medicine

OAT

Lugar: Leicester; Año: 2016 vol. 1 p. 39 - 51

Identification of mutations associated to Cystic Fibrosis (CF)was initially searched in lung cell, epithelia, mucus goblet cells, etc.However, recently it has become more obvious that cystic fibrosistransmembrane regulator (CFTR) mutation on immune cells producesdysregulation in the lung even before infections occur. In this reviewwe summarized how affects immune cells response and how it haschanged the treatments of CF.