SYNTHESIS AND CHARACTERIZATION OF NOVEL STIMULI-RESPONSIVE HYBRID POLYMERS WITH POTENTIAL APPLICATIONS IN CONTROLLED DRUG RELEASE

FRANCISCO M. PARDINI; PAULA A. FACCIA; OSCAR R. PARDINI; JAVIER I. AMALVY

Córdoba

Congreso; 3° Reunión Internacional de Ciencias Farmacéuticas; 2014

In this work,hybrids containing PU polymerized with DEA (PU/DEA), NIPA (PU/NIPA) and DPA(PU/DPA) monomers were prepared and characterized using FTIR, swelling and in-vitrodrug release at different pHs and temperatures, using Rhodamine 6G (Rh6G) as amodel of an active pharmaceutical ingredient (API).  The results show changes in the swelling degree when the temperature or pHwas modified. FTIRspectra of hybrid polymers indicate an interaction between the PU and theacrylic monomer. The PU/DEA system releases at pH 4 a large amount of Rh6G compare to pH 8.As it was expected, this behavior is also observed in the PU/DPA system in thesame conditions. Additionally, this system shows a thermo-sensitive responsewhich can be observed in the increment of Rh6G released when the temperature ismodified, from 37 °C to room temperature (22 °C). For the PU/NIPA system theamount of Rh6G released was higher at 22 °C compare to 37 °C, indicating athermo-dependence behavior. In conclusion, the copolymerization between PU and different functionalacrylic monomers allows preparing hybrids polymer films with good mechanicalproperties and stimuli-responsive characteristics suitable for drug deliveryapplications. Depending on the monomer used, systems with pH or/andthermo-sensitive properties can be obtained.