pH-Sensitive Polyurethane/Poly(2-(Diethyl Amino) Ethylmethacrylate) Hybrid Polymers For Drug Delivery Applications

FRANCISCO M. PARDINI; MARÍA G. ECHEVERRÍA; OSCAR R. PARDINI; JAVIER I. AMALVY

Córdoba

Congreso; 1° Reunión Internacional de Ciencias Farmacéuticas; 2010

Facultad de Ciencias Químicas, Universidad Nacional de Córdoba

A previous study of 2-(diethyl amino) ethylmethacrylate (DEAEMA)-based microgels (1) shows that they are film forming and pH-sensitive materials useful for drug delivery. However depending on the conditions they are difficult to handle. A convenient way to improve the physical characteristics of films is to copolymerize with vinyl-terminated polyurethanes (VTPU) to produce good film-forming hybrid material. In this work, hybrid polymers containing VTPU polymerized with different amounts of DEAEMA monomer (10 and 30 wt.%) were prepared and characterized for FTIR, DSC and in vitro drug release at different pHs using Rhodamine 6G (Rh6G) as delivery marker. The amount of Rh6G released at pH 9 is very low for VTPU and for both VTPU/DEAEMA hybrid films.The n values indicate a Fickian transport (diffusion-controlled mechanism) for VTPU/PDEAEMA:90/10 and a non-Fickian process for VTPU/PDEAEMA:70/30 at pH 4. DEAEMA monomer and VTPU can be copolymerized to prepare films suitable for drug delivery applications with variable release kinetics depending on the VTPU/DEAEMA ratio.