20 ?Analysis of the morphological remodeling of orexigenic AgRP fibers in the brain of fasted mice: a potential regulatory role of the ghrelin signaling?

CASSANO DANIELA A; FERNÁNDEZ GIMENA; DE FRANCESCO P. NICOLAS; GARCÍA ROMERO GUADALUPE; TOLOSA MARÍA JOSÉ; REYNADO MIRTA; MARIO PERELLÓ

Congreso; Sociedad Argentina de Neurociencias; 2020

Ghrelin is a stomach-derived hormone that acts via the growth hormone secretagogue receptor (GHSR). Ghrelin is essential to cope with energy deficit conditions, when plasma levels increase and activate central functions that help to maintain glycaemia and increase appetite. These ghrelin actions are mainly mediated by the agoutirelated protein (AgRP)-producing neurons of the arcuate nucleus (ARC  neurons), which innervate several appetite-related brain regions. Recently, we found that the ARC AgRP projections to the hypothalamic paraventricular nucleus are remodeled in fasting states (48 h) in a GHSR-dependent manner. Here, we tested if the fasting-induced activation of ARC AgRP AgRP   neurons promotes morphological remodeling of other hypothalamic (lateral hypothalamic area, LHA) and extra-hypothalamic (paraventricular thalamus, PVT, and central amygdala, CeA) ARC AgRP  projections and its dependence on GHSR.