INVESTIGADORES
RÚA Federico
artículos
Título:
Cyclobutyl-carbonyl substituted PNA: synthesis and study of a novel PNA derivative
Autor/es:
GEMMA AGUADO; FEDERICO RÚA; VICENÇ BRANCHADELL; PETER E. NIELSEN; ROSA MARÍA ORTUÑO
Revista:
TETRAHEDRON-ASYMMETRY
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2006 vol. 17 p. 2499 - 2503
ISSN:
0957-4166
Resumen:
A new, optically active, cyclobutyl-carbonyl substituted PNA monomer has been synthesized stereoselectively from a chiral amino acid prepared from (+)-alfa-pinene. A conformational search shows a lack of conformational bias for the monomer and incorporation of the monomer into a standard oligomer is tolerated without changing the binding affinity towards sequence complementary RNA, DNA or PNA targets.
