EXPERIMENTAL HYPERTHYROIDISM INCREASES CORPORAL WEIGHT, AND EXPAND SPLEEN AND SUPRARENAL GLANDS OF MALE AND FEMALE BALBC MICE

MOISO A; PITTON JA; SÁNCHEZ MB; MICHEL MC; VIRUEL LB; NEIRA FJ; PIETROBON EO; SOAJE M; VALERIO M; ROSALES JA; CUELLO-CARRION D; GÓMEZ S; JAHN GA; VALDEZ SR; MACKERN-OBERTI JP

Congreso; Sociedad de Biología de Cuyo; 2023

It is widely known that Hyperthyroidism (hyperT) alters endocrine status and impacts reproductive and metabolic processes. Previous reports establish that hyperT can increase corticosterone levels in a rat model. Thyroid hormones (THs) can directly regulate multiple immune populations, controlling innate and acquired immune responses. However, whether hyperT can deregulate immune cell homeostasis or it could expand immune cells in vivo remains unclear. Our work aimed to evaluate the influence of hyperT on splenic and corporal weight. To this end, 16 weeks of BALB/c mice were injected 5 times per week with s.c. 0.25 mg/kg T4 (hyperT) and vehicle (control) and euthanized on day 60. Body weight was measured once a week, and the suprarenal gland and spleen were obtained and weighed at the time of euthanasia. Our results show that hyperT mice displayed an increased weight gain from day 12 of treatment in male (p