HYPERTHYROIDISM IMPROVES GLYCEMIA CONTROL IN TYPE 1 DIABETIC NOD MICE

MAISO, A; PITTÓN, JA; SANCHEZ, M.B.; MICHEL, MC; VIRUEL, LB; NEIRA, FJ; PIETROBON, EO; SOAJE, M; VALERIO CHAVEZ, M; ROSALES, J A; CUELLO CARRIÓN, D; GOMEZ, S; JHAN, G; VALDEZ, S R; MACKERN-OVERTI, JP

San Juan

Congreso; Sociedad de Biología de Cuyo; 2023

Sociedad de Biología de Cuyo

It is widely known that Hyperthyroidism (hyperT) alters endocrine status and impacts reproductive and metabolic processes. Previousreports establish that hyperT can increase corticosterone levels in a rat model. Thyroid hormones (THs) can directly regulate multipleimmune populations, controlling innate and acquired immune responses. However, whether hyperT can deregulate immune cellhomeostasis or it could expand immune cells in vivo remains unclear. Our work aimed to evaluate the influence of hyperT on splenicand corporal weight. To this end, 16 weeks of BALB/c mice were injected 5 times per week with s.c. 0.25 mg/kg T4 (hyperT) andvehicle (control) and euthanized on day 60. Body weight was measured once a week, and the suprarenal gland and spleen wereobtained and weighed at the time of euthanasia. Our results show that hyperT mice displayed an increased weight gain from day 12 oftreatment in male (p