INVESTIGADORES
COMINI Laura Raquel
congresos y reuniones científicas
Título:
Photophysical and photosensitizing characterization of 5-Chloro-Soranjidiol
Autor/es:
J. DIMMER; L.R. COMINI; F.E. MORAN VIEYRA; R.A. MIGNONE; SC NÚÑEZ MONTOYA ; V. REY ; C.S. MENDOZA; J.L. CABRERA; C.D. BORSARELLI
Lugar:
Córdoba
Reunión:
Congreso; 16th INTERNACIONAL CONGRESS OF PHOTOBIOLOGY; 2014
Resumen:
Heterophyllaea J.D. Hook. (Rubiaceaea) is a South American genus represented by only two species,
Heterophyllaea pustulata Hook f. and Heterophyllaea lycioides (Rusby) Sandwith [1]. Our research
group succeeded in the identification of nine AQs from the first species. We demonstrated that these AQs
possess photosensitizing properties and these results led us to study them as anticancer and antimicrobial
agents to be used in photodynamic therapy, obtaining satisfactory results [2].
Recently we have started with the phytochemical study of H. lycioides and we have identified five AQs at
the moment: four previously isolated from H. pustulata and an additional new one, 5-Chloro-Soranjidiol,
recently described for this family of compounds [3]. The aim of this work is to determine photophysical
and photosensitizing properties of 5-Chloro-Soranjidiol compared with those of the parent compound
(Soranjidiol, previously isolated from H. pustulata) using steady-state and time-resolved absorption and
emission spectroscopies. The main results are summarized as follows.
The results indicate that both compounds have similar photophysical properties, with a 3-exponential
fluorescence decay component with a remarkable Stokes shift, probably by presence of several emitting
states due to the formation of tautomeric species by intramolecular H-transfer, favoring non-radiative
decay processes. However, the F for both compounds was similar and relatively efficient (0.25),
confirming the potential photodynamic activity of the Soranjidiol derivatives.
References
[1] N. Sandwith. Kew Bolletin 1949;4,253.
[2] S. Núñez, L. Comini, J. Cabrera. Antimicrobial activity of natural photosensitizing anthraquinones in
Microbioloby Book Series. Méndez-Vilas (Ed.). Formatex Research, Badajoz, 2011,3-13.
[3] J. Dimmer, S. Núñez, C. Mendoza, J. Cabrera. XIV Simposio Latinoamericano Farmacobotánica.
Rosario, 2013.