Determinación del coeficiente de partición (logP) para derivados antraquinónicos aislados de Heterophyllaea pustulata Hook. f. (Rubiáceas).

COMINI, L.R.; NÚÑEZ MONTOYA, S.C.; ARGÜELLO, GUSTAVO A.; CABRERA, J.L.

ACTA FARM. BONAERENSE

COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES

Lugar: Buenos Aires; Año: 2006 vol. 25 p. 252 - 255

0326-2383

Partition coefficient (log P) determination of anthraquinone derivatives isolated from Heterophyllaea pustulata Hook. f. (Rubiaceae)?. The anthraquinones isolated from the phototoxic species Heterophyllaea pustulata Hook. f. (Rubiáceas), soranjidiol, soranjidiol 1-methyl ether, rubiadin, rubiadin 1-methyl ether, damnacanthal and damnacanthol, are Type I and/or Type II photosensitizers. In addition, they show a potential therapeutic use according to results where extracts enriched in these metabolites and obtained from leaves and stems of H. pustulata demonstrated an important antibacterial and antifungal activity in vitro with a low acute toxicity in vivo. In order to estimate the capacity of these AQs to penetrate into the cells and their body distribution by going through biological membranes with the aim to unleash the described biological effects, we determinated the log P of each one by using the shake flash technique. Except for damnacanthol, all of the AQs tested showed a higher value of log P compared to metoprolol. In addition, the average value of log P for each AQ was similar to the theoretical value (CLogP).