CO-ELECTROSPINNING OF BIOGLASS-LOADED PCL NANOFIBERS AND AMOXICILLIN-LOADED EUDRAGIT EPO NANOFIBERS AS COATING FOR METALLIC IMPLANTS

KLOSTER, GIANINA A.; RIVERO, GUADALUPE; BALLARRE, JOSEFINA; HERRERA, KARINA; ABRAHAM, GUSTAVO A.

Mar del Plata

Congreso; XII Latin-American Congress of Artificial Organs and Biomaterials; 2023

INTEMA

The use of metallic bone implants requires surface modification to improve the material properties, e.g., by using composite polymeric coatings. Electrospinning technique is highly recommended because the nanofiber structure mimics the extracellular matrix. Poly(ε-caprolactone) (PCL) is biocompatible and biodegradable, and bioglass (BG) can be included in the fibers providing osteogenesis and angiogenesis features. Moreover, pH-responsive fibers loaded with amoxicillin (AMX) were electrospun using Eudragit-EPO (EEPO), that dissolves at pH